Antinociceptive effect of sumatriptan in mice.
Indian J Exp Biol
;
1998 Oct; 36(10): 973-9
Article
in English
| IMSEAR
| ID: sea-62065
ABSTRACT
Antinociceptive effect of the antimigraine drug sumatriptan (5-HT1A agonist) was studied against acetic acid-induced writhing in mice. Sumatriptan produced the effect in a dose-dependent manner (1, 5, 10 and 20 mg/kg, s.c.). Naloxone (1 mg/kg i.p.) an opiate antagonist failed to reverse sumatriptan-induced antinociception. Cholinomimetic physostigmine (0.05 mg/kg, i.p.) potentiated and the muscarinic antagonist atropine (5 mg/kg, i.p.) blocked the antinociceptive effect of sumatriptan, respectively. The antinociceptive effect of sumatriptan was compared with an another 5-HT agonist (5-HT1A) buspirone which also produced antinociception. Like sumatriptan-analgesia, the buspirone response was also potentiated by physostigmine in atropine sensitive way. Further, buspirone potentiated the analgesic effect of sumatriptan. These observations suggest that 5-HT1A agonists produce antinociception possibly by modulating central cholinergic activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Female
/
Male
/
Serotonin Receptor Agonists
/
Sumatriptan
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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