Trichloroethylene toxicity in mice: a biochemical, hematological and pathological assessment.
Indian J Exp Biol
;
1992 May; 30(5): 402-6
Article
in English
| IMSEAR
| ID: sea-62071
ABSTRACT
Oral administration of trichloroethylene (TCE; 0, 500, 1000 and 2000 mg/kg/day) to male mice once daily, 5 days a week for a period of 28 days, caused a significant increase in liver weight, degeneration/necrosis of hepatocytes and characteristics proliferation of endothelial cells of hepatic sinusoids. Increase in kidney weight, glomerular nephrosis, degeneration/desquamation of tubular epithelium and characteristic amyloid deposition in glomeruli were observed only in the group of mice treated with 2000 mg/kg TCE. These changes occurred concurrently with a significant increase in total protein and free sulphydryl contents, elevated activities of acid phosphatase and catalase and decreased activity of delta-aminolevulinic acid dehydratase (delta-ALAD) indicating the sensitivity of liver and kidney as target tissues in TCE-toxicity. Hematological studies showed a significant increase in RBC counts and a reduction in WBC counts without any statistically significant change in the hemoglobin, urea nitrogen, creatinine and uric acid levels in the blood of TCE-exposed mice. A dose-related increase in cell density and acid phosphatase activity with a parallel significant decrease in the activity of delta-ALAD were observed in the bone marrow, which appear to be responsible for hematological alterations in TCE-exposed mice. The results suggest that early metabolic, pathological and hematological perturbations following a short-term exposure of TCE in mice, can provide the basis for its documented potential for chronic effects like blood dyscrasia and cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Trichloroethylene
/
Body Weight
/
Bone Marrow Diseases
/
Male
/
Proteins
/
Porphobilinogen Synthase
/
Kidney
/
Kidney Diseases
/
Liver
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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