Zinc, copper and hydrolytic enzymes in epididymis of hydrocortisone treated rat.
Indian J Exp Biol
;
1998 Jan; 36(1): 22-33
Article
in English
| IMSEAR
| ID: sea-62093
ABSTRACT
Administration of glucocorticoid (1, 2 and 4 mg) in excess leads to degeneration of epididymides as supported by cellular degeneration, sperm density and morphometric measurements. Zinc level increased statistically after 1, 2 and 4 mg hydrocortisone treatment while copper increased after 1 and 2 mg treatment. Cholesterol, protein and leucine aminopeptidase levels increased and decreased significantly in caput and cauda respectively. Activity of alkaline phosphatase reduced significantly while the treatment of hydrocortisone at different doses elevated acid phosphatase, aryl sulphatase and lactate dehydrogenase activities. Evidently, these changes are as a result of onset of cellular degeneration leading to impairment of metabolic/secretory activity of epididymal cells. The possible involvement of pituitary-testis axis in hydrocortisone induced epididymal degeneration and functional inhibition has been discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arylsulfatases
/
Rats
/
Acid Phosphatase
/
Zinc
/
Male
/
Hydrocortisone
/
Rats, Sprague-Dawley
/
Copper
/
Alkaline Phosphatase
/
Epididymis
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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