Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain.
Indian J Exp Biol
;
2009 Mar; 47(3): 193-7
Article
in English
| IMSEAR
| ID: sea-62101
ABSTRACT
The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performance liquid chromatography (HPLC/PDA detector). Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose, decreased body weights and reduced cerebral adenosine levels. Administration of duloxetine (5, 10 and 20 mg/kg, ip) to diabetic mice produced dose-dependent anti-nociceptive effect in both tail-immersion and hot-plate assays. Adenosine levels were also significantly and dose-dependently increased by different doses of duloxetine. The results demonstrated the involvement of adenosinergic pathway in duloxetine mediated anti-hyperalgesia in diabetic neuropathic pain.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thiophenes
/
Touch
/
Pain Measurement
/
Male
/
Adenosine
/
Cerebral Cortex
/
Selective Serotonin Reuptake Inhibitors
/
Pain Threshold
/
Streptozocin
/
Diabetes Mellitus, Experimental
Language:
English
Journal:
Indian J Exp Biol
Year:
2009
Type:
Article
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