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Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ.
Indian J Exp Biol ; 2008 Nov; 46(11): 783-7
Article in English | IMSEAR | ID: sea-62123
ABSTRACT
FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Polymers / Scattering, Radiation / Bacterial Proteins / Recombinant Proteins / Caffeic Acids / Eugenol / Cell Division / Cinnamates / Cytoskeletal Proteins / Flavanones Type of study: Diagnostic study / Screening study Language: English Journal: Indian J Exp Biol Year: 2008 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Polymers / Scattering, Radiation / Bacterial Proteins / Recombinant Proteins / Caffeic Acids / Eugenol / Cell Division / Cinnamates / Cytoskeletal Proteins / Flavanones Type of study: Diagnostic study / Screening study Language: English Journal: Indian J Exp Biol Year: 2008 Type: Article