Glutathione as an inhibitor of trypsin induced proteolysis.
Indian J Exp Biol
;
1989 May; 27(5): 472-3
Article
in English
| IMSEAR
| ID: sea-62148
ABSTRACT
Glutathione has been shown to inhibit trypsin induced proteolytic activity. A concentration of 6 mM of glutathione was found to completely inhibit proteolysis of 3H-proline labelled underhydroxylated procollagen as a substrate, whereas a concentration of 2.1 mM of glutathione caused 50% inhibition of proteolysis. When azocoll was used as a substrate for trypsin 50% inhibition of proteolysis was achieved with 1.4 mM of glutathione, though a complete proteolytic inhibition was attained at 4 mM glutathione. The results suggest that glutathione may be playing an important role in protein metabolism in a variety of disease and stress states.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Trypsin
/
Trypsin Inhibitors
/
Procollagen
/
Fibroblasts
/
Glutathione
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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