Effect of ciprofloxacin on specific immune response in rabbits.

Jayakumar, K; Honnegowda,; Krishnappa, G; Sastry, K N V; Narayana, K

Jayakumar, K; Honnegowda,; Krishnappa, G; Sastry, K N V; Narayana, K.

Indian J Exp Biol ; 2002 Jan; 40(1): 111-4

Article in English | IMSEAR | ID: sea-62188

ABSTRACT

ABSTRACT

Ciprofloxacin (10 mg/kg body weight, iv, twice daily for 4 days) failed to alter specific antibody titres, total immunoglobulin concentration, total serum protein concentration, total leukocyte count, lymphocyte percentage, phagocytic index and skin thickness in DNCB skin sensitivity test against Brucella plain killed antigen in New Zealand White rabbits. It can be concluded that ciprofloxacin at the dose and duration employed did not adversely affect specific immune response in normal rabbits.

Subject(s)

Animals; Anti-Infective Agents/pharmacology; Brucella Vaccine/immunology; Ciprofloxacin/pharmacology; Dinitrochlorobenzene/immunology; Female; Hemolytic Plaque Technique; Immune System/drug effects; Immunity, Cellular; Immunoglobulin G/immunology; Injections, Intramuscular; Leukocyte Count; Leukocytes/immunology; Lymphocyte Activation/drug effects; Male; Phagocytosis/drug effects; Rabbits; Skin Tests

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phagocytosis / Rabbits / Female / Male / Immunoglobulin G / Skin Tests / Brucella Vaccine / Lymphocyte Activation / Ciprofloxacin / Hemolytic Plaque Technique Language: English Journal: Indian J Exp Biol Year: 2002 Type: Article

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