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Alpha1 and alpha2 adrenoceptor mediated melanosome aggregatory responses in vitro in Oreochromis mossambica (Peters) melanophores.
Indian J Exp Biol ; 2007 Nov; 45(11): 984-91
Article in English | IMSEAR | ID: sea-62220
ABSTRACT
Effects of specific and non-specific adrenoceptor agonists and antagonists were examined on the isolated scale melanophores of O. mossambica in physiological Ringer solution. The responses were recorded as melanophore size index. It was observed that adrenaline, nor-adrenaline, phenylpropanolamine, clonidine and phenylepherine induced melanosome aggregation in a dose-dependent manner. Denervation of the fish melanophores increased the sensitivity of the melanophores to adrenaline but not to nor-adrenaline. Phentolamine (3.55 x 10(-5) M), prazosin (2.38 x 10(-5) M) and yohimbine (2.821 x 10(-5) M) significantly inhibited the aggregatory responses of the fish melanophores to adrenaline, nor-adrenaline, clonidine and phenylepherine. The blocking effect of yohimbine was significantly higher than that of prazosin. It is concluded that the effect of adrenaline is directly mediated through the receptors and alpha2 adrenoceptors are predominantly involved in the aggregatory responses of this fish melanophores, while alpha1 adrenoceptors presence has been indicated.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Skin Pigmentation / Tilapia / Receptors, Adrenergic, alpha-2 / Receptors, Adrenergic, alpha-1 / Adrenergic Antagonists / Adrenergic Agonists / Melanosomes / Dose-Response Relationship, Drug Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Skin Pigmentation / Tilapia / Receptors, Adrenergic, alpha-2 / Receptors, Adrenergic, alpha-1 / Adrenergic Antagonists / Adrenergic Agonists / Melanosomes / Dose-Response Relationship, Drug Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article