Low incidence of CNS relapse with cranial radiotherapy and intrathecal methotrexate in acute lymphoblastic leukemia.
Indian Pediatr
;
1996 Jul; 33(7): 556-60
Article
in English
| IMSEAR
| ID: sea-6223
ABSTRACT
OBJECTIVES:
To assess the incidence of isolated central nervous system (CNS) relapses in patients of acute lymphoblastic leukemia (ALL) treated with a protocol containing cranial irradiation and intrathecal methotrexate as CNS directed therapy.DESIGN:
Prospective non randomized study.SETTING:
Department of Medical Oncology, Tata Memorial Hospital.SUBJECTS:
623 children of ALL on MCP 841.METHODS:
CNS relapse was diagnosed, if upon examination of the CSF, more than 50 cells/microliter were observed, or a count of 5 cells which were unequivocally lymphoblasts.RESULTS:
The incidence of isolated CNS relapse was 1.75% with the use of this treatment. Age, sex, white blood cell count, platelet count, lactic dehydrogenase and immunophenotyping were not significantly related to isolated CNS relapse.CONCLUSION:
A low incidence of isolated CNS relapse demonstrates the adequacy of the presymptomatic CNS therapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Central Nervous System
/
Child
/
Child, Preschool
/
Methotrexate
/
Cranial Irradiation
/
Adolescent
/
Leukemic Infiltration
Type of study:
Controlled clinical trial
/
Practice guideline
/
Incidence study
Language:
English
Journal:
Indian Pediatr
Year:
1996
Type:
Article
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