Effect of nimesulide co-administration on pharmacokinetics of lithium.
Indian J Exp Biol
;
2004 Dec; 42(12): 1248-50
Article
in English
| IMSEAR
| ID: sea-62237
ABSTRACT
In a crossover study, lithium was given orally at a dose of 56 mg/kg, prepared as suspension (0.5%) in carboxymethyl cellulose (CMC) and blood samples (1 ml) collected after 0-24 hr after drug administration. After a washout period of two weeks, nimesulide (10 mg/kg) was administered alongwith lithium (56 mg/kg) and blood samples were drawn at the same time intervals (0-24 hr) after drug administration. Plasma was separated and assayed for lithium by M 654 Na+/K+/Li+ analyzer and various pharmacokinetic parameters were calculated. C(max), K(el), t(1/2el) and AUC(0-alpha) of lithium were significantly increased when nimesulide was administered along with lithium as compared to control group.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Sulfonamides
/
Antipsychotic Agents
/
Male
/
Anti-Inflammatory Agents, Non-Steroidal
/
Drug Interactions
/
Lithium
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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