Effect of B-HT 920 on cardiotoxic effects of ouabain in guinea pigs.
Indian J Exp Biol
;
1991 Nov; 29(11): 1084-6
Article
in English
| IMSEAR
| ID: sea-62279
ABSTRACT
Effect of B-HT 920, a selective alpha 2 adrenoceptor agonist, was studied on ouabain induced cardiac arrhythmias and cardiac arrest in guinea pigs. Ventricular premature beats, ventricular tachyarrhythmias and cardiac arrest were induced in anaesthetized guinea pigs by slow infusion of ouabain. B-HT 920 accorded significant protection to guinea pigs against ouabain induced arrhythmias. Yohimbine inhibited the antiarrhythmic effect of B-HT 920 significantly. It is concluded that the protective effect of B-HT 920 against ouabain induced cardiac arrhythmias and cardiac arrest is mediated through the stimulation of alpha 2 adrenoceptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ouabain
/
Arrhythmias, Cardiac
/
Azepines
/
Female
/
Male
/
Adrenergic alpha-Agonists
/
Guinea Pigs
/
Heart
/
Heart Arrest
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
Similar
MEDLINE
...
LILACS
LIS