Subacute toxicity of anilofos, a new organophosphorus herbicide, in male rats: effect on some physical attributes and acetylcholinesterase activity.
Indian J Exp Biol
;
2001 Nov; 39(11): 1107-12
Article
in English
| IMSEAR
| ID: sea-62351
ABSTRACT
In acute toxicity study, rats showed dose-dependent signs of cholinergic hyperactivity and behavioural alterations. Maximum intensity of symptoms was not associated with mortality. Oral LD50 was 1681 mg/kg. In subacute toxicity study, rats were orally administered 50, 100 or 200 mg/kg of anilofos once daily for 28 days. Signs and symptoms were observed mainly with 200mg/kg. At this dose, anilofos induced hypothermia and progressive weight loss. None of the anilofos-treated rats died. Weight of brain, lung, testis was not altered, while of liver, heart, spleen and kidney increased. Anilofos inhibited cholinesterase (ChE) activities of erythrocyte (41-67%), plasma (36%), blood (37-64%), brain (63-73%) and liver (28-48%). Total protein was decreased in plasma and liver. Results indicate moderate toxic potential of anilofos in mammals, substantial contribution of CNS-mediated effects in causing anilofos toxicity and no direct relationship between hypothermia and level of ChE inhibition.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Organophosphorus Compounds
/
Acetylcholinesterase
/
Rats
/
Brain
/
Male
/
Cholinesterase Inhibitors
/
Rats, Wistar
/
Herbicides
/
Lethal Dose 50
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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