Effect of new diamidines against Leishmania donovani infection.
Indian J Exp Biol
;
1993 Feb; 31(2): 196-8
Article
in English
| IMSEAR
| ID: sea-62439
ABSTRACT
The impact of interamidine distance on antileishmanial activity of new aryldiamidines have been evaluated against amastigotes of L. donovani in hamster. Of the 20 compounds tested, only four (2,8-diamidino-9,10-dihydrodibenzoxepin; 2,7-diamidinoxanthone; 2,7-diamidinothioxanthone and 2,7-diamidinoxanthene) showed significant inhibition (more than 80%) of multiplication of amastigotes in spleen. The interamidine distance in the structure appears to have bearing on antileishmanial activity. The observations made are likely to evoke new understanding on the structure activity relationship of diarylamidines.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Structure-Activity Relationship
/
Male
/
Cricetinae
/
Mesocricetus
/
Drug Evaluation, Preclinical
/
Amidines
/
Leishmaniasis, Visceral
/
Animals
/
Antiprotozoal Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
1993
Type:
Article
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