Steroid receptors in mammary glands and tumors of hysterectomised rats.

ABSTRACT

Epidemiological survey suggests that longer exposure of the breast to sex steroids may be one of the factors involved in increased risk for cancer. Using an experimental model of bilaterally hysterectomised rats, the sex steroid receptors in the mammary glands during growth as well as incidence and hormonal characteristics of chemically induced mammary tumors have been studied. Though steroid receptors were detectable in the mammary glands of the model earlier than in intact rats, the incidence or hormone dependency of the mammary tumors in the two groups were not considerably altered.