Detection of mutagenicity in cervico-vaginal secretions--a plausible risk factor for cervical cancer.
Indian J Exp Biol
;
1990 Jul; 28(7): 601-4
Article
in English
| IMSEAR
| ID: sea-62549
ABSTRACT
The cervico-vaginal secretions from 51 women with various grades of dysplastic lesions of uterine cervix were assessed for mutagenic potential by Ames test using histidine deficient mutant strain of Salmonella typhimurium TA-98 with S-9 mix. Twenty three per cent of samples from women with cervical dysplasia were found significantly positive (P less than 0.001) for mutagenic activity compared to 3% positive from control. The frequency of mutagenic secretions detected were almost uniform, irrespective of the severity of cervical lesions. None of cervico-vaginal secretions, positive for mutagenicity could revert the tester strain when tested in absence of S-9 mix (liver microsomal enzymes). This indicates that mutagens in cervico-vaginal secretions are effective only when activated enzymatically.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Salmonella typhimurium
/
Female
/
Humans
/
Male
/
Biotransformation
/
Uterine Cervical Dysplasia
/
Cervix Mucus
/
Animals
/
Mutagenicity Tests
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
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