Assay of carcinogenicity of tobacco metabolites employing microsomal degranulation technique.
Indian J Exp Biol
;
1998 May; 36(5): 483-7
Article
in English
| IMSEAR
| ID: sea-62578
ABSTRACT
Carcinogenicity of salivarty extracts of different types of tobaccos smoked and chewed in India and Pan Parag were tested using microsomal degranulation technique. Results obtained on the basis of RNA/protein ratios (Indices to confirm the detachment of ribosomes from microsomes) showed that tobaccos used for cigarette, bidi, hukah and chewing tobacco with lime as well as Pan Parag were positively carcinogenic. Two fractions out of 7 isolated chromatographically from salivary extract of chewing tobacco plus lime were found to be carcinogenic. Elemental and spectral analyses indicated that the fractions are possibly an aromatic compound with an aliphatic side chain and N-(buty1 nitrosamine)-1-(3-pyridyl)-4-hydroxy-1-butanone.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Toxic
/
Saliva
/
Nicotiana
/
Microsomes, Liver
/
Carcinogenicity Tests
/
Cell Degranulation
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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