Nucleolar organizer region heteromorphism associated with trisomy-21: a risk factor for non-disjunction?
Article
in English
| IMSEAR
| ID: sea-62648
ABSTRACT
An unusual nucleolar organizer region (double NOR) on chromosome 13 was observed in a Down syndrome child [47, XY, +21, dNOR(13)]. The variant chromosome was inherited from the mother [46, XX, dNOR(13)]. The extra chromosome 21 in the proband was maternal origin. The frequency of NOR chromosome association showed relatively high frequency in the mother and proband as compared to the controls. The result suggest that chromosome variants involving extra copies of NOR may indeed be involved in the meiotic nondisjunction of chromosome-21.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Nondisjunction, Genetic
/
Male
/
Child, Preschool
/
Risk Factors
/
Down Syndrome
/
Nucleolus Organizer Region
Type of study:
Etiology study
/
Risk factors
Language:
English
Year:
1989
Type:
Article
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