Enteral erythropoietin increases plasma erythropoietin level in preterm infants: a randomized controlled trial.
Indian Pediatr
;
2008 Jan; 45(1): 25-8
Article
in English
| IMSEAR
| ID: sea-6265
ABSTRACT
OBJECTIVE:
To evaluate the effects of enteral administration of recombinant human erythropoietin (rhEPO) on serum level of erythropoietin and erythropoiesis in preterm infants. STUDYDESIGN:
Randomized controlled trial.SETTING:
Level III NICU.SUBJECTS:
16 preterm infants less than 34 wk with birth weight less than 1800 g. INTERVENTION Enteral rhEPO 400 U/kg, three times/week, plus FeSO4,3-6 mg/Kg/day ( Study group, n = 7) or FeSO4 only (Control group, n = 9). OUTCOMEMEASURES:
Hemoglobin, serum erythropoietin (EPO), reticulocyte count, and serum ferritin levels, measured at baseline, after 10 days and at discharge.RESULTS:
Mean birth weight and gestational age for the Study and the Control groups were 1328.5 +/- 267.4 vs. 1392.8 +/- 196.7 g and 30.7 +/- 2.5 vs. 30.2 +/- 0.9 weeks, respectively. At discharge, there was no difference in hemoglobin or hematocrit but the reticulocyte counts were significantly higher in the Study group (1.4 +/- 0.7 vs. 0.7 +/- 0.4, P = 0.03). Serum erythropoietin level was significantly higher in the Study group (18 +/- 11 vs. 8.6 +/- 3.9 mU/mL, P = 0.006). Conversely, serum ferritin level was lower in the study group but did not achieve statistical significance.CONCLUSIONS:
Enteral administration of rhEPO in preterm infants resulted in increase in serum erythropoietin and reticulocyte counts at the time of discharge without significantly affecting hemoglobin or hematocrit.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Infant, Low Birth Weight
/
Infant, Newborn
/
Infant, Premature
/
Erythropoietin
/
Enteral Nutrition
/
Reticulocyte Count
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian Pediatr
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS