Effect of calcium-channel blocking drugs on focal ventricular arrhythmias induced by sub-epicardial epinephrine infusion in cats.
Indian J Exp Biol
;
1998 Mar; 36(3): 311-4
Article
in English
| IMSEAR
| ID: sea-62719
ABSTRACT
Sub-epicardial infusion of epinephrine (EP) in the dose of 3 x 10(-3) M in 2.5 x 10(-3) M CaCl2-0.9% NaCl (calcium-saline vehicle) at the rate of 10 microliters in the right ventricular myocardium of mongrel cats weighing between 2.8 and 3.3 kg, produced uniform, reversible and reproducible focal ventricular arrhythmia (VA) of varrying intensity and duration. Infusion of two calcium-channel blocking agents, verapamil (VP) and nifedipine (ND) at the site of arrhythmogenesis, in equimolar concentration of 3 x 10(-3) M alongwith EP in the same vehicle reduced the incidence, duration, peak and mean frequencies of arrhythmias while, the latent period of onset of arrhythmias increased significantly. Verapamil in equimolar concentration of 3 x 10(-3) M was found to be more effective than nifedipine in antagonizing EP-induced ventricular arrhythmias.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pericardium
/
Arrhythmias, Cardiac
/
Female
/
Male
/
Calcium Channel Blockers
/
Nifedipine
/
Epinephrine
/
Cats
/
Heart Ventricles
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS