Experimental therapeutic intervention with ascorbic acid in ethanol induced testicular injuries in rats.

Maneesh, M; Jayalakshmi, H; Dutta, Sanjiba; Chakrabarti, Amit; Vasudevan, D M

Maneesh, M; Jayalakshmi, H; Dutta, Sanjiba; Chakrabarti, Amit; Vasudevan, D M.

Indian J Exp Biol ; 2005 Feb; 43(2): 172-6

Article in English | IMSEAR | ID: sea-62734

ABSTRACT

ABSTRACT

Ascorbic acid treatment significantly increased the activities of testicular delta5, 3beta-HSD and 17beta-HSD. Moreover, the treatment was also associated with significant decrease in oxidative stress in the testis. Ethanol induced oxidative stress and decreased steroidogenesis can be reversed by treatment with ascorbic acid.

Subject(s)

Administration, Oral; Animals; Antioxidants/therapeutic use; Ascorbic Acid/therapeutic use; Body Weight/drug effects; Ethanol/toxicity; Glutathione/metabolism; Gonadal Steroid Hormones/biosynthesis; Lipid Peroxides/metabolism; Male; Oxidative Stress/drug effects; Rats; Testis/drug effects

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Ascorbic Acid / Rats / Gonadal Steroid Hormones / Testis / Body Weight / Male / Administration, Oral / Oxidative Stress / Ethanol / Glutathione Language: English Journal: Indian J Exp Biol Year: 2005 Type: Article

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