Effect of ATP sensitive potassium channel modifiers on antinociceptive effect of metoclopramide.
Indian J Exp Biol
;
2001 May; 39(5): 476-8
Article
in English
| IMSEAR
| ID: sea-62878
ABSTRACT
Metoclopramide, a prokinetic drug, has been documented to produce antinociceptive response in animal models through opioid pathways. Morphine has been shown to act through ATP sensitive potassium channels (KATP) to produce antinociceptive response. However, such a possibility has not been examined for metoclopramide. The present study investigated this using pharmacological tools. Acetic acid induced abdominal constriction assay procedure was utilized to assess antinociception. The results confirmed that metoclopramide has antinociceptive response. Glibenclamide, a KATP channel blocker, pretreatment antagonized this response. Where as, in minoxidil pretreated animals, metoclopramide elicited an enhanced antinociceptive response. Glibenclamide and minoxidil, which are known KATP channel blocker and opener respectively, interfered with metoclopramide antinociception. These finding are suggestive of a role for KATP channels in metoclopramide antinociception in mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain Measurement
/
Male
/
Potassium Channels
/
Adenosine Triphosphate
/
Glyburide
/
Potassium Channel Blockers
/
Drug Interactions
/
Analgesics
/
Animals
/
Metoclopramide
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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