In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.
Indian J Exp Biol
;
2005 Mar; 43(3): 291-3
Article
in English
| IMSEAR
| ID: sea-62942
ABSTRACT
Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE and CA increased significantly as compared to normal control when treated with lynestrenol at 13.75 and 27.50 mg/kg body wt. The present results suggest that lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sister Chromatid Exchange
/
Body Weight
/
DNA Damage
/
Female
/
Bone Marrow Cells
/
Chromosome Aberrations
/
Contraceptives, Oral, Synthetic
/
Lynestrenol
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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