Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats.
Indian J Exp Biol
;
2006 Mar; 44(3): 209-15
Article
in English
| IMSEAR
| ID: sea-62980
ABSTRACT
Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aspartate Aminotransferases
/
Rats
/
Male
/
Cardiotonic Agents
/
Rats, Wistar
/
Xanthones
/
Alanine Transaminase
/
Dose-Response Relationship, Drug
/
Isoproterenol
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2006
Type:
Article
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