Effect of doxorubicin on heart mitochondrial enzymes in rats: a protective role for alpha-tocopherol.
Indian J Exp Biol
;
1992 Jul; 30(7): 615-8
Article
in English
| IMSEAR
| ID: sea-63004
ABSTRACT
Effect of doxorubicin on heart mitochondrial enzymes was studied in rats with or without the administration of alpha-tocopherol. Rats were treated with doxorubicin 2.5 mg/kg, ip body wt once a week for 8 weeks. Alpha-tocopherol was co-administered orally for 2 months (400 mg/kg body wt daily). TCA cycle enzyme, NADH-dehydrogenase, cytochrome-C-oxidase and Na+,K(+)-ATPase activities were found to be decreased in doxorubicin treatment. A significant decrease in protease activity was observed with a concomitant increase in mitochondrial protein level. Mitochondrial lipid peroxide level was found to be increased with a decrease in thiol content. Alpha-tocopherol co-administration was found to maintain the mitochondrial enzyme activities as well as the thiol content. The results are discussed with reference to the antioxidant nature of alpha-tocopherol.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Vitamin E
/
Male
/
Lipid Peroxidation
/
Doxorubicin
/
Rats, Wistar
/
Animals
/
Mitochondria
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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