In vitro anti-oxidant property of protein-A of Staphylococcus aureus.
Indian J Exp Biol
;
1991 Dec; 29(12): 1130-3
Article
in English
| IMSEAR
| ID: sea-63027
ABSTRACT
Protein-A (PA) is a cell-surface glycoprotein of S. aureus Cowan I with immunomodulatory and anti-tumor activities, and ability to ameliorate cyclophosphamide and carbontetrachloride (CCl4) induced toxicity in rodents. The likely mechanism of this effect appears to be the anti-oxidant property of PA, evidenced in the present study by inhibition of CCl4 and Fe2-ascorbate induced lipid peroxidation in rat liver homogenates and inhibition of deaminative-oxidative degradation of L-glutamate into 2-thiobarbituric acid reactive products in a constituted chemical system. The anti-oxidant property of PA seem to arise from its molecular characteristics and the ability to interact with a superoxide derived free-radical species without any affinity for superoxide anion, hydroxyl radical and singlet oxygen species.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Staphylococcal Protein A
/
Staphylococcus aureus
/
Male
/
Carbon Tetrachloride
/
Lipid Peroxidation
/
Cyclophosphamide
/
Free Radicals
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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