Alprazolam modifies animal behaviour on elevated plus-maze.
Indian J Exp Biol
;
1993 Nov; 31(11): 908-11
Article
in English
| IMSEAR
| ID: sea-63031
ABSTRACT
Exposure to elevated plus-maze is known to evoke approach-avoidance conflict behaviour and anxiety related movements in mice. Alprazolam (0.1 to 1 mg/kg, ip) produced dose dependant increase in antianxiety response, 100% first preference to open arm, open arm entries and exploratory behaviour. This effect was not only comparable to diazepam but also sensitive to reversal by flumazenil, a benzodiazepine receptor antagonist. Withdrawal of alprazolam (2 mg/kg/day for 14 days) and diazepam (20 mg/kg/day for 14 days) from chronic treatment produced typical anxiety response in animals. When tested for transfer latency, a parameter for learning and memory, both diazepam and alprazolam interfered with cognitive behaviour. Besides these actions, alprazolam also possesses anti-depressant property which makes it an atypical benzodiazepine for anxiety, panic disorder and endogenous depression.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Anxiety
/
Anti-Anxiety Agents
/
Behavior, Animal
/
Alprazolam
/
Substance-Related Disorders
/
Diazepam
/
Learning
/
Animals
/
Mice
/
Mice, Inbred BALB C
Language:
English
Journal:
Indian J Exp Biol
Year:
1993
Type:
Article
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