Tri-ortho-cresyl phosphate induced neurotarget esterase inhibition in brain and peripheral nerve effectively monitored by lymphocytes.
Indian J Exp Biol
;
1994 May; 32(5): 356-9
Article
in English
| IMSEAR
| ID: sea-63033
ABSTRACT
Tri-ortho-cresyl phosphate ester (TOCP 10-100 mg/kg)--an organophosphorus compound (OP) inhibited brain, peripheral nerve and lymphocyte neurotarget esterase activities in a dose related and time-dependent manner. There was a good correlation of inhibition between brain, peripheral nerve and lymphocyte tissues taken from adult hens treated with 3 different doses of TOCP and sacrificed 24 and 48 hr after exposure. The results suggest that lymphocyte can effectively monitor OP compounds for investigating inhibition of neurotarget esterase activity in brain and peripheral nerve tissues.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Peripheral Nerves
/
Tritolyl Phosphates
/
Brain
/
Female
/
Carboxylic Ester Hydrolases
/
Lymphocytes
/
Chickens
/
Drug Monitoring
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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