Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice.
Indian J Exp Biol
;
2002 May; 40(5): 546-54
Article
in English
| IMSEAR
| ID: sea-63038
ABSTRACT
Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Behavior, Animal
/
Female
/
Fluorides
/
Hippocampus
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
2002
Type:
Article
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