Effect of antimicrobials on cholesterol synthesis and content in liver and small intestines.

Pugalendhi, K V; Sudhakaran, P R; Ramakrishnan, S

Pugalendhi, K V; Sudhakaran, P R; Ramakrishnan, S.

Indian J Exp Biol ; 1992 Feb; 30(2): 152-4

Article in English | IMSEAR | ID: sea-63051

ABSTRACT

ABSTRACT

The antimicrobials tetracycline, ampicillin and bactrim (cotrimoxazole) decreased HMG CoA reductase activity in liver and small intestines of albino rats. Diminished incorporation of 1, 2, 14C acetate into cholesterol of small intestines in bactrim group was noted. There was a significant fall in cholesterol content of liver, duodenum, jejunum and ileum of the bactrim group and jejunum only in tetracycline group.

Subject(s)

Ampicillin/pharmacology; Animals; Cholesterol/biosynthesis; Hydroxymethylglutaryl CoA Reductases/metabolism; Intestine, Small/drug effects; Liver/drug effects; Rats; Tetracycline/pharmacology; Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Tetracycline / Trimethoprim, Sulfamethoxazole Drug Combination / Cholesterol / Ampicillin / Hydroxymethylglutaryl CoA Reductases / Intestine, Small / Liver / Animals Language: English Journal: Indian J Exp Biol Year: 1992 Type: Article

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