Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.
Indian J Exp Biol
;
2004 Jun; 42(6): 567-9
Article
in English
| IMSEAR
| ID: sea-63185
ABSTRACT
Biliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions on guinea pig ileum. Acetylcholine (10-640 ng/ml) induced concentration-dependent contraction of smooth muscle. Diclofenac, in varying concentration (9.4 x 10(-5) mol/l and 14.1 x 10(-5) mol/l) shifted the concentration response curve of acetylcholine to the right without suppressing the maximal response. However, in higher concentration diclofenac (18.9 x 10(-5) mol/l) blocked the response in an unsurmountable fashion. Further, analgin (11.09 x 10(-5), 16.63 x 10(-5) and 22.18 x 10(-5) mol/l) in equimolar concentrations did not alter the concentration response curve of acetylcholine, but in higher concentration analgin (44.36 x 10(-5) mol/l) also blocked the response in an unsurmountable fashion. Pitofenone (2.5 x 10(-6) mol/l) also, shifted the concentration response curve of acetylcholine to right in a parallel fashion with no change in maximal response. The present study confirms the potent antispasmodic activity of diclofenac-pitofenone combination in comparison to analgin-pitofenone in molar equivalent concentration (in comparison to diclofenac) against acetylcholine-induced contractions of guinea pig ileum.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Parasympatholytics
/
Spasm
/
Benzophenones
/
Female
/
Male
/
Acetylcholine
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diclofenac
/
Dipyrone
/
Cholinergic Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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