Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+.
Indian J Exp Biol
;
2004 May; 42(5): 481-5
Article
in English
| IMSEAR
| ID: sea-63299
ABSTRACT
Histamine reduced sperm viability in a dose- and time-dependent manner, accompanied by rise in intrasperm Ca2+. Further, 2',4'-dichlorobenzamil hydrochloride (DBZ), a Na+-Ca2+ exchange inhibitor, known to elevate intrasperm Ca2+, potentiated both, elevation of intrasperm Ca2+ and spermicidal action of histamine. Pretreatment of sperm with very low doses of H1-receptor antagonists (chlorpheniramine, promethazine or diphenhydramine) prevented the histamine-induced elevation of intrasperm Ca2+ as well as its spermicidal action. However, pretreatment with famotidine, a H2-receptor antagonist did not produce such a protective action. The results strongly suggest that histamine elicits its spermicidal action via H1-receptors present on sperm cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Promethazine
/
Sperm Motility
/
Spermatozoa
/
Time Factors
/
Humans
/
Male
/
Histamine
/
Cell Survival
/
Chlorpheniramine
/
Calcium
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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