Postnatal survival and growth of mouse irradiated in utero with low dose.
Indian J Exp Biol
;
1996 Sep; 34(9): 883-6
Article
in English
| IMSEAR
| ID: sea-63355
ABSTRACT
In order to investigate radiation risks associated with low dose and low dose-rates, pregnant Swiss albino mice were exposed to gamma rays, 0.80 Gy from a cobalt-60 source at two different dose-rates (0.0795 and 0.0012 Gy/min) on 18 day post conception. In females exposed to lower dose-rate (0.0012 Gy/min), litter size was found to be decreased, while those exposed to higher dose-rate (0.0795 Gy/min), it remained unaltered. In both groups, appearance of fur and development of complete fur were delayed, whereas gait was delayed only in higher dose-rate group. Male offspring exhibited a biphasic mode of weight loss, while female offspring after an initial weight loss at 1 week, displayed a continuous recovery, but could not attain the normal weight till 12 weeks of age. It appears that higher dose-rate is more effective in delaying the appearance of physiological markers and weight loss, while in terms of litter size lower dose-rate (0.0012 Gy/min) is more effective.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prenatal Exposure Delayed Effects
/
Radiation Dosage
/
Female
/
Male
/
Pregnancy
/
Survival Rate
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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