Anti-secretagogue effect of lithium on isolated rat islets of Langerhans.
Indian J Exp Biol
;
1989 Feb; 27(2): 163-5
Article
in English
| IMSEAR
| ID: sea-63410
ABSTRACT
Administration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Islets of Langerhans
/
Insulin
/
Lithium
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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