In vitro cytotoxic effect of new diphenylphosphinoethane-copper(I) complexes on human ovarian carcinoma cells.
Indian J Exp Biol
;
1997 Aug; 35(8): 810-4
Article
in English
| IMSEAR
| ID: sea-63450
ABSTRACT
Five new copper (I) complexes have been tested for their, in vitro cytotoxicity on chinese hamster ovary (CHO) and human ovarian carcinoma PA-1 cell lines using MTT assay. The compounds exhibited encouraging cytotoxicity at of 1, 2, 4 & 8 micrograms/ml doses. They were further tested for cytotoxicity on human ovarian carcinoma cells obtained from five different patients previously untreated with antineoplastic drugs and radiation. Standard antitumor drugs like cis-platin, adriamycin and etoposide were also included as positive control. Cytotoxicity of compounds C3, C4 and C5 (IC50 0.7, 1.25 and 1.4 micrograms/ml respectively) was found to be superior to adriamycin (IC50 2.8 micrograms/ml) but less effective than cisplatin (IC50 < 0.1 microgram/ml) on human ovarian carcinoma cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organometallic Compounds
/
Organophosphorus Compounds
/
Ovarian Neoplasms
/
Female
/
Humans
/
Drug Screening Assays, Antitumor
/
Tumor Cells, Cultured
/
Cricetinae
/
CHO Cells
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1997
Type:
Article
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