Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Indian J Exp Biol
;
2003 Dec; 41(12): 1460-2
Article
in English
| IMSEAR
| ID: sea-63457
ABSTRACT
Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20, 40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependant manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Triterpenes
/
Male
/
Cell Degranulation
/
Adjuvants, Immunologic
/
Rats, Wistar
/
Boswellia
/
Dose-Response Relationship, Drug
/
Anaphylaxis
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2003
Type:
Article
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