Gastro-duodenal mucosal changes associated with low-dose aspirin therapy: a prospective, endoscopic study.
Article
in English
| IMSEAR
| ID: sea-63687
ABSTRACT
OBJECTIVES:
The association of low-dose aspirin use and gastro-intestinal bleeding is well described. However, the gastroduodenal mucosal changes associated with low-dose aspirin therapy have not been properly evaluated. We undertook a prospective, endoscopic study to evaluate gastro-duodenal mucosal lesions produced by low-dose aspirin.METHODS:
Forty-seven patients with non-hemorrhagic cerebral infarct or transient ischemic attacks and normal upper gastrointestinal endoscopy were randomized to receive either enteric-coated (n=25) or plain (n=22) aspirin (150 mg/day). Follow-up endoscopy was done at 2, 4 and 8 weeks; gastro-duodenal mucosal lesions, if present, were scored. Forty-seven patients with hemorrhagic infarct who were not treated with aspirin served as controls.RESULTS:
Twenty eight (60%) of 47 patients receiving aspirin had mucosal lesions; stomach alone was the most frequent site (32%), followed by both stomach and duodenum (23%). Frequency of mucosal changes in the stomach at 8 weeks (19%) was significantly lower (p<0.05) than those at 2 weeks (53%) and 4 weeks (55%). Coated (56%) and plain (63.6%) aspirin induced mucosal lesions with similar frequency.CONCLUSION:
Administration of low-dose aspirin, either plain or enteric-coated, induces endoscopic gastro-duodenal mucosal lesions in a large majority of patients. The frequency of damage decreased after 8 weeks of therapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Reference Values
/
Tablets, Enteric-Coated
/
Aged
/
Female
/
Humans
/
Male
/
Drug Administration Schedule
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Cerebral Infarction
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Ischemic Attack, Transient
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Anti-Inflammatory Agents, Non-Steroidal
Type of study:
Controlled clinical trial
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Etiology study
/
Observational study
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Prognostic study
/
Risk factors
Language:
English
Year:
2001
Type:
Article
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