Submucosal hypoganglionosis causing chronic idiopathic intestinal pseudo-obstruction.
Article
in English
| IMSEAR
| ID: sea-64095
ABSTRACT
A 39-year-old woman presented with recurrent symptoms suggestive of intestinal obstruction. She was put on total parenteral nutrition (TPN) and consequently developed sepsis and endocarditis. TPN was stopped and a venting enterostomy was performed. Biopsies of mucosa and submucosa were taken at surgery; immunohistochemistry for neuronal proteins, protein gene product 9.5 (PGP 9.5) and the glial S-100-protein was done. Many enlarged nerve fiber strands were found in the submucosa. Few small ganglia containing a small number of nerve cells could be observed, suggesting hypoganglionosis. This patient with chronic idiopathic intestinal pseudoobstruction of neurogenic type had a defect in the submucous plexus, whereas visceral neuropathies are usually characterized by defects of the myenteric plexus with normal submucous plexus.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Submucous Plexus
/
Intestinal Pseudo-Obstruction
/
Female
/
Humans
/
Chronic Disease
/
Adult
/
Hirschsprung Disease
/
Ileum
Language:
English
Year:
2002
Type:
Article
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