Tumor necrosis factor-alpha gene promoter polymorphism in Iranian patients with chronic hepatitis B.
Article
in English
| IMSEAR
| ID: sea-64298
ABSTRACT
BACKGROUND:
Clearance of hepatitis B virus (HBV) infection requires a good host immune response. Cytokines like tumor necrosis factor-alpha (TNF- alpha) may play a role in such immune response. Genetic changes in TNF-a gene promoter region are known to influence TNF- alpha expression. We therefore studied the role of one such mutation in chronic HBV infection.METHODS:
Presence of -308 G/A polymorphism in the promoter region of TNF- alpha gene was looked for in 100 patients with chronic HBV infection, 91 subjects with spontaneously recovered HBV infection and 89 healthy controls, using a PCR-RFLP method.RESULTS:
Variant alleles (A/A or A/G) were found in 22 of 100 (22%) patients with chronic HBV infection, 21 of 91 (23%) subjects with spontaneous HBV clearance and 14 of 89 (15.7%) control subjects (p=ns for inter-group comparisons).CONCLUSION:
TNF- alpha promoter polymorphism -308A is common in Iranian population, but has no association with development of chronic HBV infection.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Humans
/
Chi-Square Distribution
/
Promoter Regions, Genetic
/
Tumor Necrosis Factor-alpha
/
Hepatitis B, Chronic
/
Alleles
/
Gene Frequency
/
Iran
Country/Region as subject:
Asia
Language:
English
Year:
2006
Type:
Article
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