Effect of sucralfate on gastric bicarbonate secretion in patients with duodenal ulcer.
Article
in English
| IMSEAR
| ID: sea-64498
ABSTRACT
BACKGROUND:
Sucralfate is known to protect gastroduodenal mucosa and thereby facilitate healing of peptic ulcer. The mechanism of action of this drug is still not fully known.METHODS:
We studied the effect of sucralfate treatment on gastric bicarbonate secretion in 16 patients with duodenal ulcer.RESULTS:
Sucralfate administration (3 g daily for 4 weeks) stimulated bicarbonate secretion from 3.1 +/- 1.2 mmol/h to 4.6 +/- 2.0 mmol/h (p < 0.05). Gastric juice volume as well as non-parietal volume secretion also increased significantly after sucralfate therapy (p < 0.05).CONCLUSION:
Sucralfate causes stimulation of non-parietal volume-dependent gastric bicarbonate secretion.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stimulation, Chemical
/
Bicarbonates
/
Sucralfate
/
Humans
/
Drug Administration Schedule
/
Adult
/
Duodenal Ulcer
/
Gastric Juice
/
Gastric Mucosa
/
Middle Aged
Language:
English
Year:
1995
Type:
Article
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