Cholestatic jaundice during infancy: experience at a tertiary-care center in Bangladesh.
Article
in English
| IMSEAR
| ID: sea-64527
ABSTRACT
BACKGROUND AND OBJECTIVE:
Cholestatic jaundice in early infancy is a difficult diagnostic problem. Early diagnosis is important for proper management. This retrospective study was conducted to find out the etiology and clinical profile of neonatal cholestatic disorders in Bangladesh.SETTING:
Tertiary-care hospital in a developing country.METHODS:
Clinical profile and cause of cholestatic illness were studied in 62 infants with cholestatic jaundice developing before three months of age and persisting for more than two weeks.RESULTS:
Neonatal hepatitis (22; 35.5%--17 with TORCH, 5 with urinary infection), followed by biliary atresia (16; 25.8%) and idiopathic neonatal hepatitis (15; 24.2%), were the commonest causes of cholestasis. Mean age at presentation was 3.5 months. Ten (62.5%) of 16 biliary atresia cases were male and jaundice appeared before 14 days in 14 (87.5%) cases.CONCLUSIONS:
Neonatal hepatitis, biliary atresia and idiopathic neonatal hepatitis were the common causes of neonatal cholestasis in infancy. Though cholestatic jaundice developed early, most of the cases presented late.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bangladesh
/
Humans
/
Infant, Newborn
/
Jaundice, Obstructive
/
Infant
Type of study:
Observational study
/
Screening study
Country/Region as subject:
Asia
Language:
English
Year:
2005
Type:
Article
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