Portal hypertensive jejunopathy: a case control study.
Article
in English
| IMSEAR
| ID: sea-64633
ABSTRACT
BACKGROUND:
Small bowel mucosa is a recognized potential source of bleeding in portal hypertension. However, the frequency of its involvement is not known.AIMS:
To document the nature, severity and frequency of endoscopic and histologic changes in the jejunum in patients with portal hypertension.METHODS:
Forty consecutive patients with portal hypertension and 43 patients with non-ulcer dyspepsia (controls) underwent push enteroscopy and jejunal, duodenal and gastric biopsies. Biopsies were randomized and examined by a blinded pathologist for inflammation and vascular dilatation, which was quantified by morphometry.RESULTS:
Endoscopic jejunopathy was observed in 6 patients and none of the control subjects. All patients with jejunopathy had portal hypertensive gastropathy (PHG) and 5 had duodenopathy. Vascular dilatation was observed in 15 patients and 25 control subjects (p = ns). The degree of vascular dilatation was similar in both groups. Inflammatory changes were observed in 24 patients and 25 control subjects (p = 0.05).CONCLUSIONS:
Endoscopic jejunopathy was present in 15% of patients with portal hypertension. These changes were mild in 83% of them. All patients with jejunopathy also had PHG. Histologic changes were similar in patients and control subjects.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Severity of Illness Index
/
Aged
/
Female
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Humans
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Male
/
Case-Control Studies
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Prevalence
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Endoscopy, Digestive System
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Adolescent
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Adult
Type of study:
Controlled clinical trial
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Observational study
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Prevalence study
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Risk factors
Language:
English
Year:
2004
Type:
Article
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