Effect of cimetidine on hepatotoxicity induced by isoniazid-rifampicin combination in rabbits.
Article
in English
| IMSEAR
| ID: sea-64854
ABSTRACT
OBJECTIVE:
To evaluate the hepatoprotective potential of cimetidine in hepatotoxicity induced by isoniazid-rifampicin combination in albino rabbits.METHODS:
Six groups of six rabbits each were studied. Three groups received saline (control), isoniazid (50 mg/Kg/d) alone or isoniazid with rifampicin (100 mg/Kg/d) daily orally for 7 days. Other groups received intraperitoneal cimetidine (50 mg/Kg/d) alone or cimetidine (50 or 120 mg/Kg/d) along with isoniazid-rifampicin combination. Serum levels of liver enzymes were measured at baseline and on day 8 and liver histology was studied on day 8.RESULTS:
Rabbits receiving isoniazid alone for 7 days showed no increase in serum ALT and AST levels, whereas those receiving isoniazid-rifampicin combination had a 3-4-fold increase in these levels (p=0.02). Animals receiving cimetidine pre-treatment did not show a significant increase in ALT and AST levels. Histological changes in the liver were more common with isoniazid-rifampicin combination than with isoniazid only. These changes were reduced in animals receiving low-dose cimetidine and prevented in those receiving high-dose cimetidine.CONCLUSION:
Cimetidine in high dose can prevent hepatotoxicity induced by isoniazid-rifampicin combination.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Rifampin
/
Cimetidine
/
Statistics, Nonparametric
/
Chemical and Drug Induced Liver Injury
/
Histamine H2 Antagonists
/
Isoniazid
/
Liver Function Tests
/
Animals
/
Antitubercular Agents
Language:
English
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS