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Spectrum of viral hepatitis in thalassemic children receiving multiple blood transfusions.
Article in English | IMSEAR | ID: sea-64968
ABSTRACT

AIM:

To investigate the prevalence of infection with hepatitis viruses in children with thalassemia receiving multiple blood transfusions.

METHODS:

Sera from 50 children with thalassemia aged 5-15 years (30 boys), who had each received over 80 units of blood, were evaluated for the presence of markers for hepatitis A virus (HAV; IgG and IgM anti-HAV), hepatitis B virus (HBV; HBsAg, and IgG and IgM anti-HBc), hepatitis C virus (HCV; IgG and IgM anti-HCV, and HCV RNA) and hepatitis E virus (HEV; IgG and IgM anti-HEV). IgM anti-hepatitis D virus (HDV) was looked for only in HBsAg or IgM anti-HBc positive sera.

RESULTS:

No child had evidence of recent HAV or HDV infection. IgG anti-HAV was positive in 12 children. One patient had acute HBV infection. Nine patients were HBsAg-positive. HCV infection was present in 15 cases; six of them were HCV RNA positive, and three had superinfection with hepatitis B. Recent HEV infection was present in 5 cases.

CONCLUSION:

Thalassemic patients receiving multiple blood transfusions often acquire hepatitis B (20%) and C (30%) infections. Recent hepatitis E infection was documented in 10% in this one-point study.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thalassemia / Blood Transfusion / Humans / Male / Child / Child, Preschool / Hepatitis B virus / Cross-Sectional Studies / Adolescent / Hepatitis E virus Type of study: Observational study / Prevalence study / Risk factors Language: English Year: 2002 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thalassemia / Blood Transfusion / Humans / Male / Child / Child, Preschool / Hepatitis B virus / Cross-Sectional Studies / Adolescent / Hepatitis E virus Type of study: Observational study / Prevalence study / Risk factors Language: English Year: 2002 Type: Article