Effect of diazepam sedation on arterial oxygen saturation during esophagogastroduodenoscopy: a placebo-controlled study.
Article
in English
| IMSEAR
| ID: sea-65051
ABSTRACT
OBJECTIVE:
To determine the effect of sedation using diazepam on hemoglobin oxygen saturation (SpO2) in patients undergoing esophagogastroduodenoscopy (EGD).METHOD:
100 consecutive patients scheduled for EGD were randomly allocated to receive 0.03 mL/Kg of either diazepam (5 mg/mL solution) or normal saline intravenously after topical oropharyngeal anesthesia immediately before the procedure. SpO2 was continuously monitored throughout the procedure by an anesthetist who was unaware of the drug received.RESULTS:
Fall in SpO2 exceeding 4% was noted in 78% of patients in the diazepam group and in 38% of patients in the placebo group (p < 0.001). Fall in SpO2 to suboptimal level (89%) was seen in 20% of patients in the diazepam group and in 10% patients in the placebo group (p < 0.001). The duration of suboptimal SpO2 was similar (means +/- SD being 2.47 +/- 0.10 min in diazepam group and 2.86 +/- 0.32 min in placebo group).CONCLUSION:
Intravenous diazepam administration before EGD produces a significant fall in SpO2 during the procedure, and so should be avoided; continuous monitoring of SpO2 should be done during EGD.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxygen
/
Humans
/
Hemoglobins
/
Conscious Sedation
/
Endoscopy, Digestive System
/
Adult
/
Diazepam
/
Hypnotics and Sedatives
/
Middle Aged
Type of study:
Controlled clinical trial
Language:
English
Year:
1996
Type:
Article
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