Ten-year serological follow up of hepatitis B vaccine recipients.
Article
in English
| IMSEAR
| ID: sea-65322
ABSTRACT
AIM:
To determine long-term persistence of antibodies to hepatitis B surface antigen (anti-HBs) after vaccination against hepatitis B.METHODS:
Thirty-four laboratory workers received hepatitis B vaccine in 1989 in a 0-1-6 month vaccination schedule. Group A (n = 16) received a booster at 3 years after vaccination whereas Group B (n = 18) did not. Anti-HBs was quantitated at 1 month and 1, 2, 3, 5, 6 and 8 years post-vaccination.RESULTS:
At eight-year follow up, 10 of 15 subjects in Group A and 3 of 16 in Group B had protective levels of anti-HBs; in addition, two and four subjects, respectively, had detectable anti-HBs though below protective levels. At ten years, 9/15 and 3/16 were anti-HBs positive in Groups A and B, respectively. One subject in each group had rise in anti-HBs titer at 6-year follow up but both of them tested negative for IgG antibodies to hepatitis B core antigen (anti-HBc). A booster dose at 10 years to anti-HBs negative subjects led to an anamestic response in 3/4 and 8/10 persons in Groups A and B, respectively.CONCLUSION:
Immunological memory after vaccination against hepatitis B is maintained for at least 10 years.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Female
/
Humans
/
Male
/
Enzyme-Linked Immunosorbent Assay
/
Cohort Studies
/
Follow-Up Studies
/
Sensitivity and Specificity
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Hepatitis B Vaccines
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Adult
Type of study:
Diagnostic study
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Etiology study
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Evaluation studies
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Incidence study
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Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2000
Type:
Article
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