Helicobacter pylori-associated gastritis and gastric cancer in Nigeria.
Article
in English
| IMSEAR
| ID: sea-65333
ABSTRACT
BACKGROUND:
The etiology of gastric cancer has not been clearly delineated. There is some evidence of an association of gastric cancer with Helicobacter pylori-induced chronic gastritis, atrophic gastritis and intestinal metaplasia. Previous studies report a high rate of H. pylori infection and chronic gastritis among Nigerians.METHODS:
We retrospectively reviewed 84 tissue specimens with gastric cancer seen in our department over an 18-year period for for the presence of H. pylori infection, chronic gastritis, atrophic gastritis, and intestinal metaplasia in the adjacent non-cancerous gastric mucosa.RESULTS:
H. pylori infection was detected in 15 (17.9%) of 84 specimens. Moderate to severe gastritis was found in non-cancerous areas in 77 (91.7%) specimens, and was equally frequent in patients with 'intestinal' and 'diffuse' types of cancer. Atrophic gastritis and intestinal metaplasia were observed in 22 (26.2%) and 35 (41.7%) specimens, respectively, and were more common in 'intestinal' type of gastric cancer.CONCLUSION:
Chronic gastritis was seen in the adjacent non-cancerous mucosa in most specimens with gastric cancer. However, its severity did not correlate with the histological subtype of gastric cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stomach Neoplasms
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Adenocarcinoma
/
Chi-Square Distribution
/
Retrospective Studies
/
Helicobacter pylori
Type of study:
Observational study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Africa
Language:
English
Year:
2003
Type:
Article
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