Neurologic deterioration in a child with Wilson's disease on penicillamine therapy.

Paul, Alexander Chandran; Varkki, Sneha; Yohannan, Nisha B; Eapen, C E; Chandy, George; Raghupathy, P

Paul, Alexander Chandran; Varkki, Sneha; Yohannan, Nisha B; Eapen, C E; Chandy, George; Raghupathy, P.

Article in English | IMSEAR | ID: sea-65618

ABSTRACT

ABSTRACT

Penicillamine is the standard therapy for Wilson's disease in children. We report an 8-year-old-girl with liver disease due to Wilson's disease who developed extrapyramidal symptoms following administration of penicillamine. Symptoms resolved within 20 hours of stopping the drug but recurred within 24 hours when gradually increasing small doses were recommenced.

Subject(s)

Chelating Agents/adverse effects; Child; Dose-Response Relationship, Drug; Female; Hepatolenticular Degeneration/drug therapy; Humans; Neurodegenerative Diseases/chemically induced; Penicillamine/adverse effects; Syndrome

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Penicillamine / Syndrome / Female / Humans / Chelating Agents / Child / Neurodegenerative Diseases / Dose-Response Relationship, Drug / Hepatolenticular Degeneration Language: English Year: 2003 Type: Article

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