Antibodies to Cag A protein are not predictive of serious gastroduodenal disease in Indian patients.
Article
in English
| IMSEAR
| ID: sea-65746
ABSTRACT
OBJECTIVE:
The present study was aimed at assessing the predictive utility of anti-Cag A antibodies in differentiating patients of duodenal ulcer (DU) and non ulcer dyspepsia (NUD) from asymptomatic controls in a developing country.METHODS:
Sera from 120 subjects were tested for antibodies to Cag A using the immunodominant portion of a recombinant 37.5 kDa fusion protein by ELISA, in endoscopically proven cases of DU and NUD and healthy controls.RESULTS:
The observed optical density (OD) in DU and NUD patients was 1,947 and 1,960 respectively, which was higher than that observed in controls (p < 0.01), but there was no difference in the anti-Cag A antibody titers between DU and NUD patients.CONCLUSION:
Anti-Cag A antibodies do not seem to discriminate duodenal ulcer patients from non ulcer dyspepsia in the Indian population.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bacterial Proteins
/
Aged
/
Female
/
Humans
/
Male
/
Enzyme-Linked Immunosorbent Assay
/
Case-Control Studies
/
Prevalence
/
Predictive Value of Tests
/
ROC Curve
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Year:
1998
Type:
Article
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