Serum hyaluronic acid concentrations in children with cirrhosis.
Article
in English
| IMSEAR
| ID: sea-65764
ABSTRACT
BACKGROUND:
Liver disease is associated with increased levels of hyaluronic acid (HA).AIM:
To evaluate serum HA concentrations in children with cirrhosis and its relation with liver function tests and Child-Pugh score.METHODS:
Twenty-two children with biopsy-proven liver cirrhosis were studied. All were assessed for the presence of ascites or encephalopathy and liver function tests were performed. Patients were categorized according to Child-Pugh criteria. Serum HA was measured using microELISA (normal 0-100 ng/mL). Twenty-two children with chronic hepatitis B and no cirrhosis were studied as controls.RESULTS:
Serum HA level in the cirrhotic children was 85.2 (72.8) ng/mL; levels were high (166.0 [46.3] ng/mL; range 115-246) in 8 (36.4%) patients. Three of 11 (27.2%) Child-Pugh class A patients, 3 of 8 (37.5%) class B patients, and 2 of 3 (66.7%) class C patients had elevated serum HA values (p=ns). Serum HA levels correlated with direct bilirubin level. The control group had lower levels (4.8 [2.3] ng/mL; p< 0.05), which were in the normal range.CONCLUSION:
Serum HA level may be useful as a diagnostic tool in children with cirrhosis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Reference Values
/
Biopsy, Needle
/
Severity of Illness Index
/
Female
/
Humans
/
Male
/
Biomarkers
/
Case-Control Studies
/
Child
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS