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Dystrophin gene deletions in South Indian Duchenne muscular dystrophy patients.
Indian J Med Sci ; 2003 Jan; 57(1): 1-6
Article in English | IMSEAR | ID: sea-66395
ABSTRACT
66 unrelated patients from Southern India with Duchenne Muscular Dystrophy (DMD) were studied for intragenic deletion in 18 exons and Pm region of the DMD gene using multiplex PCR. Of these 41 (62.1%) showed intragenic deletions. 78% of the deletions were located at the distal hotspot region (44-55 exons) and 22% of the deletions were located at the proximal region (exon 2-19). Exon 50 is most frequently deleted. Deletions in isolated cases were significantly more compared to familial cases. The lower incidence reported from South India compared to North India, is suggestive of variations in the Southern and Northern population.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Dystrophin / Gene Deletion / Muscular Dystrophy, Duchenne / India Country/Region as subject: Asia Language: English Journal: Indian J Med Sci Year: 2003 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Dystrophin / Gene Deletion / Muscular Dystrophy, Duchenne / India Country/Region as subject: Asia Language: English Journal: Indian J Med Sci Year: 2003 Type: Article